We brew twice in a day, and at the end of every brew day run a caustic cleaning loop in reverse.
When rinsing out that caustic, running the rinse as fast as possible (effectively a backflush) dislodges all the crap the cleaning process has lifted but not removed.
So yeah... a reverse loop clean and then a combined rinse and backflush. I've followed a few different procedures before, and this is my pick.
What's your end-of-week regimen?